Venetoclax (ABT-199, GDC-0199) BK

Venetoclax (ABT-199, GDC-0199) BKVenetoclax (ABT 199, GDC 0199) is a Bcl 2 selective inhibitor with Ki of <0. 01 nM in cell free assays, >4800 fold more selective versus Bcl xL and Bcl w, and no activity to Mcl 1. Phase 3.

-adrenergic agonist

10-Phenanthroline is a classic chelating bidentate ligand for transition metal ions that has played an important role in the development of coordination chemistry

a plant phenolic compound

VX-809 (Lumacaftor) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation

1000-fold selectivity over other methyltransferases and other non-epigenetic targets

a bile acid formed in the liver of most species

Pyridoxine

has a variety of biological activities such as anticancer

4 mM for glycolysis/hexokinase inhibition

used to treat abnormal menstruation or irregular vaginal bleeding

140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays

BI2536 is a potent Plk1 inhibitor with IC50 of 0